3D Microscopy at the Speed of Life
Introduction
What if we could capture stunning 3D images of living cells, tissues—or even a tiny zebrafish brain—in real time, without staining, freezing, or harming them? This isn’t science fiction—it’s the focus of a groundbreaking international research collaboration in snapshot 3D microscopy, led by Prof. Humeyra Caglayan.
In the latest episode of Under the Microscope, host Dr. Pranoti Kshirsagar speaks with Prof. Caglayan about the innovative imaging techniques her team is developing—techniques that could revolutionize live cell imaging, biomedical diagnostics, and even brain research.
This research and podcast episode were supported by funding from the Jane and Aatos Erkko Foundation, showcasing how strategic science communication can amplify the visibility and impact of cutting-edge scientific work.
Key Takeaways
🔬 1. Snapshot 3D Microscopy: A New Paradigm
Traditional imaging often sacrifices speed for resolution, especially in live biological systems. Snapshot 3D microscopy removes this trade-off, enabling high-resolution volumetric images in milliseconds.
🧠 2. Meta-Optics: Seeing Beyond the Surface
The team is using novel meta-optics to extend the depth of field, capturing entire biological volumes in focus without the need for layer-by-layer scanning. This makes the process faster, more accurate, and non-destructive.
⚡ 3. Real-Time Imaging for Real-World Applications
From understanding neuronal activity in zebrafish to imagining its future role in surgical diagnostics, this technology opens new doors for both research and clinical use.
🤝 4. Interdisciplinary Innovation
The success of this project lies in the collaboration between optical physicists, imaging software developers, and biomedical scientists—demonstrating how interdisciplinary teams can tackle complex challenges.
Meet the Project Partners
- Prof. Humeyra Caglayan (Lead PI) – ORCID
- Haobijam Johnson Singh – Researcher Profile
- Jani Mäkinen – Personal Research Profile | ORCID
- 3D Media Group – Research Group Website
- CIVIT – Research Infrastructure Unit
Further Reading & Resources
- “Flat lens for snapshot 3D microscopy” — Nanophotonics, 2023
- “A practical guide to scanning light-field microscopy with digital adaptive optics” — Nat Protoc 17, 1953–1979 (2022). DOI
